A fluid flow monitoring and control system for a self-propelled applicator which may be a sprayer and is configured to allow real-time visual monitoring of graphical representations of system statuses, control of the systems, and coordinated control instructions for multiple tasks through a single user input or command. The fluid flow monitoring and control system may include a touchscreen HMI providing electronic control and monitoring for the systems and components of the applicator. A rules engine may be implemented to prevent erroneous states, such as activating a pump without fluid flow to the pump as a rule implemented interlock to prevent inadvertent rapid component wear or other compromises of system integrity.
