Neal S. Bricker,Stewart Shankel,Christopher D. Cain,Mark A. Mitchnick,Michael Schmertzler
申请号：
US14249802
公开号：
US10370335B2
申请日:
2014.04.10
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention relates to diuretic pharmaceutical compositions and methods and in particular to certain derivatives of the formula Iwherein R1, R2, R3, R5, R6 and R7 are independently X3R where R is selected from the group consisting of H, halo； optionally substituted saccharide, aliphatic, cycloalkyl, heterocycloalkyl, aryl and heteroaryl； —；P(O)(ORa)(ORb) and —；NRaRb, where Ra and Rb are independently H, optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl；X1, X2 and X3 are independently —；C(O)O—；, —；OC(O)—；, —；C(O)NH—；, —；NHC(O)—；, —；OC(O)NH—；, —；NHC(O)O—；, —；OS(O)y—；, —；S(O)y—；, —；O—；, —；NHC(O)—；, —；NHC(O)O—；, —；S(O)2NH—；, a bond or absent； where y is an integer from 0 to 3； andR4 and R8 are independently H, (═；O)； hydroxy； or optionally substituted saccharide, aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl； or —；P(O)(ORa)(ORb) or —；NRaRb, where Ra and Rb are independently H, or optionally substituted aliphatic, cycloalkyl or heterocycloalkyl, aryl or heteroaryl； ora prodrug or pharmaceutically acceptable salt thereof； anda pharmaceutically acceptable carrier.
