A therapeutic device against cancer spread and metastasis specifically integrates recovery therapy with operative chemo-radiotherapy and is used for prevention and treatment of cancer spread and metastasis. This is a device comprising multifunctional friction heads (1) coupled to low and medium frequency DC, a housing (2) with a motor mounted therein, a switch (3), a handle (4), and an integration of laser, ultrasound, microwave, radiofrequency, and medicine intervention. By evenly cooperating medication massage, electrically stimulation, deep heating, medication injection and anticancer medicine, the therapeutic device can recover function of lesion region and prevent cancer cell spread.