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鉀離子競爭性酸阻滯劑的晶型及其製備方法
专利权人:
LTD.;JIANGSU HANSOH PHARMACEUTICAL GROUP LIANYUNGANG HONGCHUANG PHARMACEUTICAL CO.
发明人:
TANG, HONGWEI,唐红伟,唐紅偉,SUN, CHANGAN,孙长安,孫長安,WANG, RUIJUN,王瑞军,王瑞軍,YUAN, HENGLI,袁恒立
申请号:
TW104137333
公开号:
TW201617336A
申请日:
2015.11.12
申请国别(地区):
TW
年份:
2016
代理人:
摘要:
The present invention discloses a crystal of potassium ion competitive acid blocker and preparation method thereof. In particular, the present invention relates to a potassium ion competitive acid blocker, namely 1-[5-(2-fluorophenyl)-1-(pyridin-3-yl sulfonyl)-1H-pyrrol-3-yl]-N-methyl-methylamine fumarate (hereinafter referred to as formula I) in crystalline form and a preparation method thereof, having an X-ray powder diffraction pattern with characteristic peaks comprising 2 θ values (± 0.2 °) measured by CuKa1 radiation: 12.30, 13.59, 15.34, 18.67, 20.48, 21.69, 25.23, 26.92. Type I polymorph of the present invention is stable, reproducible and suitable for drug development.本發明涉及鉀離子競爭性酸阻滯劑,即1-[5-(2-氟苯基)-1-(吡啶-3-基磺醯基)-1H-吡咯-3-基]-N-甲基甲胺富馬酸鹽(以下簡稱式I)的晶型及其製備方法,其X射線粉末衍射特徵峰如第1圖所示。本發明所提供的式I晶型性狀穩定,可重複性好,適合藥物開發。
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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