TAM, TIM,N&APOSZEMBA, BLAISE,LEUNG-TOUNG, REGIS,WANG, YINGSHENG,ZHAO, YANQING,YU, LILY
申请号：
PE0009792012
公开号：
PE16422012A1
申请日:
2007.12.14
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Referring to a pharmaceutically acceptable Salt isoglutamil - D - D - tryptophan of formulas (i), (ii) and (iii) in its Crystalline or Amorphous forms.In the formula (i), where M is the Potassium or lithium, potassium salt Crystal presents a pattern of x-ray Powder diffraction for values 2 Theta 9.91, 14.84, 15.81, 18.97, 19.76, 32,15, 24.36, 24,82, 23,87, 27.49, 27.94, 28.42, 30.82, 25,00 31,69, 2:17, 34,35 35.81 and the,,, and P \u00c0ra Crystal Salt Lithium has Spikes of 13.57, 15.53, 18.71, 20.11, 23:34, 24.1, 62, 27,31, 27.72, 30,50, 29,31, 30.19mm, 31.21, 32.06 33,62 37.41 31,17,, and. In the formula (ii), B is Calcium or Magnesium, where the Crystalline Salt of magnesium has Spikes of 12.2, 9,24, 14.84 16:16, 17.96, 18.52, 18,94, 19.49, 21.05, 21.56, 22.56, 23,36, 24,12, 26,27, 27.65, 28.42, 29.14, 31,77 32,62 33,38 30.55,,, 35.05, 41,71 37,22 38.05,, and.In the formula (iii) is TERT butylammonium, tris (hydroxymethyl) methylammonium or n-methyl-d - glucosilamonio. Also refers to a process of Preparation and Pharmaceutical compositionREFERIDA A UNA SAL FARMACEUTICAMENTE ACEPTABLE DE D-ISOGLUTAMIL-D-TRIPTOFANO DE FORMULAS (I), (II) Y (III), EN SUS FORMAS AMORFAS O CRISTALINAS. PARA LA FORMULA (I), M ES POTASIO O LITIO, DONDE PARA LA SAL CRISTALINA DE POTASIO SE PRESENTA UN PATRON DE DIFRACCION DE RAYOS X EN POLVO PARA VALORES 2-THETA DE 9,91, 14,84, 15,81, 18,97, 19,76, 24,04, 24,36, 24,82, 25,48, 27,49, 27,94, 28,42, 30,82, 31,28, 31,69, 32,17, 34,35, 35,81 Y 36,96, Y PÀRA LA SAL CRISTALINA DE LITIO PRESENTA PICOS DE 13,57, 15,53, 18,71, 20,11, 23,34, 24,1, 25,09, 27,31, 27,72, 28,39, 29,31, 30,19, 31,21, 32,06, 33,05, 33,62 Y 37,41. PARA LA FORMULA (II), B ES CALCIO O MAGNESIO, DONDE PARA LA SAL CRISTALINA DE MAGNESIO PRESENTA PICOS DE 12,2, 13,74, 14,84, 16,16, 17,96, 18,52, 18,94, 19,49, 21,05, 21,56, 22,56, 23,36, 24,12, 26,27, 27,65, 28,42, 29,14, 30,55, 31,77, 32,62, 33,26, 35,05, 36,34, 37,22 Y 38,05. PARA LA FORMULA (III), A ES TERT-BUTILAMONIO, TRIS(
