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Suspension for oral administration comprising amorphous tolvaptan
专利权人:
Ltd.;Otsuka Pharmaceutical Co.
发明人:
Akagi, Akitsuna,Suzuki, Kai,Nakamura, Atsuya,Nishibayashi, Toru
申请号:
AU2014221630
公开号:
AU2014221630B2
申请日:
2014.02.28
申请国别(地区):
AU
年份:
2018
代理人:
摘要:
This invention provides a suspension for oral administration comprising particles containing amorphous tolvaptan that can inhibit or delay crystallization of amorphous tolvaptan over time in the suspension, and stably maintain high solubility of tolvaptan and excellent absorbability of tolvaptan from the gastrointestinal tract; and a solid formulation for oral administration that can be suspended to prepare the suspension for oral administration at the time of use. This invention relates to a suspension for oral administration, in particular, a syrup, comprising (a) particles containing amorphous tolvaptan, (b) hydroxypropyl methylcellulose (HPMC), and (c) a solvent, wherein the amount of the HPMC (b) is 0.1 to 25% by weight based on the total weight of the suspension for oral administration.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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