WALLING, JOHN,PARENT, STEPHAN D.,JONAITIS, DAVID T.,KRAL, ROBERT M.
申请号：
CA2696330
公开号：
CA2696330C
申请日:
2008.08.14
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
A triterpenoid compound, methyl 2-cyano-3,12-dioxoleana- 1,9(11)-dien-28-oate(CDDO methyl ester), has a non--crystalline,glassy solid form and a non-hydrous crystalline form that can prepared, forexample, from a saturated methanol solution.The glassy form displays an enhanced bioavailability over the non-hydrouscrystalline form. Each form of CDDO methyl esteris a superior candidate for use, typically in solid dosage form, for treatinga variety of disease states, generally associated withinflammation.
