PROBLEM TO BE SOLVED: To provide a composition and a method for cancer immunotherapy which results in the systemic liquidation of both solid and metastatic tumors wherever they reside in the body.SOLUTION: The invention provides a therapeutic composition comprising at least one foreign antigen, at least one Type I inflammatory cytokine and at least one effector molecule capable of causing maturation of dendritic cells. The composition includes activated allogeneic Th1 cells that lead to liquidation of tumors when administered appropriately. The method includes administering priming doses of the composition, ablation of a selected tumor lesion along with intratumoral injection of the composition and then infusion of the therapeutic composition.EFFECT: These steps enable the systemic liquidation of tumors secondary to immune cell infiltration and leads to immune-mediated tumor eradication.SELECTED DRAWING: Figure 1【課題】固形腫瘍と転移性腫瘍の両方が体内のどこに存在しても、全身性の一掃をもたらす、癌の免疫療法のための組成物と方法の提供。【解決手段】少なくとも１つの外来抗原、少なくとも１つの１型炎症性サイトカイン、及び樹状細胞の成熟を引き起こすことが可能な少なくとも１つのエフェクター分子を含む治療用組成物。前記組成物が適切に投与された場合には腫瘍の一掃につながる活性化同種異系Ｔｈ１細胞を含む。前記組成物のプライミング用量を投与すること、前記組成物を腫瘍内の注射とともに選別した腫瘍の病変のアブレーション、そして前記治療用組成物の注入を含む。【効果】免疫細胞浸潤に続発する腫瘍の全身性の一掃を可能にし、及び免疫を媒介とする腫瘍根絶につながる。【選択図】図１
