A COMPOUND OF FORMULA I: EACH VARIABLE IS DEFINED IN THE SPECIFICATION. THIS INVENTION RELATES TO A METHOD OF DECREASING A LEVEL OF A CYTOKINE (E.G., TNFα OR INTERLUKINE SUCH AS IL-1β) IN A SUBJECT WITH A COMPOUND OF FORMULA I. IT ALSO RELATES TO A METHOD OF TREATING A DISORDER MEDIATED BY AN OVERPRODUCTION OF A CYTOKINE WITH SUCH A COMPOUND.