ITO HIROKO,伊藤 浩子,ITO HITOSHI,伊藤 均,FUJISHIMA MASAKI,藤島 雅基,OKUMURA ERI,奥村 衣梨
申请号：
JP2018098349
公开号：
JP2019202953A
申请日:
2018.05.22
申请国别(地区):
JP
年份:
2019
代理人:
摘要：
To provide an activator of a hematopoietic precursor cell obtained from chlorella and a recovering agent of hematopoietic injury caused by radiation or the like.SOLUTION: There are provided an activator of a hematopoietic precursor cell and a hematopoietic injury recovering agent which have physicochemical properties (a) to (e), and have peptide hetero glycan as an active ingredient. (a) Average molecular weight of 1,000,000； (b) specific rotatory power [α]-11.6(25°C)； (c) nitrogen content of 5.39%, protein content of 29.5%, polysaccharide content of 70.3%； (d) saccharide composition (molar ratio): Gal:GIc:Man:Xyl:Rha:Ara:Fru=32:25:13:8:7:5:3； (e) amino acid composition (mol%): Glu 15.1, Asp 13.8, Ala 9.9, Leu 8.9, Thr 6.5, Lys 6.2, Va1 5.9, Gly 5.8, Pro 5.5, Ser 5.4, Arg 4.8, Phe 3.6, Ileu 3.1, Tyr 2.1, His 1.7, Met 1.6, Cys 0.1, 100% in total.SELECTED DRAWING: None【課題】クロレラから得られる造血系前駆細胞の賦活剤及び放射線等による造血障害の回復剤の提供。【解決手段】理化学的性質(a)乃至(e)を有し、ペプチドヘテログリカンを有効成分とする造血系前駆細胞の賦活剤及び造血障害回復剤。(a)平均分子量１００万；(b)比旋光度〔α〕Ｄ-11.6（２５℃）；(c)窒素含量5.39%、蛋白質含量29.5%、多糖含量70.3%；(d)糖組成（モル比）：Gal:GIc:Man:Xyl:Rha:Ara:Fru=32:25:13:8:7:5:3；(e)アミノ酸組成（モル％）：Glu 15.1、Asp 13.8、Ala 9.9、Leu 8.9、Thr 6.5、Lys 6.2、Va1 5.9、Gly 5.8、Pro 5.5、Ser 5.4、Arg 4.8、Phe 3.6、Ileu 3.1、Tyr 2.1、His 1.7、Met 1.6、Cys 0.1、合計100%。【選択図】なし
