Gregor James MacDonald,José Manuel Bartolomé-Nebreda,Michiel Luc Maria Van Gool
申请号：
US12597164
公开号：
US08933101B2
申请日:
2008.04.18
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to [1-(benzyl)-piperidin-4-yl]-([1,3,4]thiadiazol-2-yl)-amine and [1-(benzyl)-piperidin-4-yl]-(thiazol-2-yl)-amine derivatives of formula (I) that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects.
