A method for automatically measuring interventricular septum thickness is provided. The method in one embodiment comprises acquiring a series of ultrasound images of a heart, acquiring a septum mask by applying a septum segmentation algorithm on the series of ultrasound images, localizing a mitral valve tip using a valve tip localization algorithm and calculating the thickness of the interventricular septum using an interventricular septum thickness algorithm. The interventricular septum thickness algorithm uses the septum mask and the localized mitral valve tip as inputs.