Kortikospinale øvre motorneuroner, fremgangsmåder og sammensætninger til differentiering af neurale stamceller ved modulering af CB1-cannabinoidreceptorsignalering og anvendelser deraf
Centro De Investigacíon Biomédica En Red De Enfermedades Neurodegenerativas Ciberned;Universidad Complutense De Madrid
发明人:
Aguado Sanchez, Tania,Díaz-Alonso, Javier,Galve-Roperh, Ismael,Guzmán Pastor, Manuel,Paraíso Luna, Juan
申请号：
DK20120382455T
公开号：
DK2733205(T3)
申请日:
2012.11.20
申请国别(地区):
丹麦
年份:
2018
代理人:
摘要：
The present invention relates to compositions and methods for obtaining a corticospinal upper motor neuron from a neural stem cell comprising the use of a CB 1 cannabinoid receptor agonist, or the use of an inhibitor of an endocannabinoid-degrading enzyme, or the modification of a neural stem cell to decrease the expression of an endocannabinoid-degrading enzyme under basal levels or to increase the expression of the CB 1 cannabinoid receptor above basal levels. The invention also relates to the corticospinal upper motor neurons obtained and uses thereof.
