A combination of osteopontin (OPN) and 2'-fucosyllactose (2-FL) is used in the prevention or the treatment of immunological diseases or disorders due to inflammatory factors secretion affecting a human or an animal subject. The said combination is useful, in particular, in the prevention or the treatment of diseases or disorders due cytokine secretion, e.g. INF-?, IL-2, IL-4, IL-17, IL-6, IL-10, TGF-ß, Tbet, GATA3 and NFkB and / or immunoglobulin secretion, e.g. IgE and Ig1.