TRABANCO-SUÁREZ, ANDRÉS, AVELINO,GIJSEN, HENRICUS, JACOBUS, MARIA,SURKYN, MICHEL,PROKOPCOVÁ, HANA
申请号：
MYPI 2014700925
公开号：
MY165209A
申请日:
2012.12.04
申请国别(地区):
MY
年份:
2018
代理人:
摘要：
THE INVENTION RELATES TO NOVEL 6-DIFLUOROMETHYL-5,6-DIHYDRO-2H-[I,4]OXAZIN-3- AMINE DERIVATIVES AS INHIBITORS OF BETA-SECRETASE, ALSO KNOWN AS BETA-SITE AMYLOID CLEAVING ENZYME, BACE, BACE1, ASP2, OR MEMAPSIN2. THE INVENTION IS ALSO DIRECTED TO PHARMACEUTICAL COMPOSITIONS COMPRISING SUCH COMPOUNDS, TO PROCESSES FOR PREPARING SUCH COMPOUNDS AND COMPOSITIONS, AND TO THE USE OF SUCH COMPOUNDS AND COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF DISORDERS IN WHICH BETA-SECRETASE IS INVOLVED, SUCH AS ALZHEIMER'S DISEASE (AD), MILD COGNITIVE IMPAIRMENT, SENILITY, DEMENTIA, DEMENTIA WITH LEWY BODIES, CEREBRAL AMYLOID ANGIOPATHY, MULTI-INFARCT DEMENTIA, DOWN'S SYNDROME, DEMENTIA ASSOCIATED WITH STROKE, DEMENTIA ASSOCIATED WITH PARKINSON'S DISEASE AND DEMENTIA ASSOCIATED WITH BETA-AMYLOID. (NO SUITABLE FIGURE)
