The disclosure provides a new and distinct hybrid melon variety NUN 16177 MEM as well as seeds and plants and fruits thereof. NUN 16177 MEM is a Cantaloupe non-sutured melon variety of the Golden subtype with long shelf-life, ovate shape, strong orange rind color and moderate orange flesh, comprising resistance to Podosphaera xanthii Race 1, Race 2, Race 5, Fusarium oxysporum melonis Race 0, Race 1, and Race 2, and Aphis gossypii.