PROBLEM TO BE SOLVED: To provide an agent which can induce the expression of an oxidation stress protection gene group, without applying an oxidation stress stimulus, in systemic organs, particularly solid organs.SOLUTION: This invention provides an agent comprising lansoprazole for the induction of the expression of an oxidation stress protection gene, for example Ahr, Cyp1, Nrf2, HO-1 or the like, and a preventive and/or therapeutic agent of an oxidation stress disease.【課題】全身臓器、特に実質臓器で、酸化ストレス刺激を加えることなく、酸化ストレス防御遺伝子群の発現を誘導し得る薬剤を提供すること。【解決手段】ランソプラゾールを含有してなる、酸化ストレス防御遺伝子、例えばAhr、Cyp１、Nrf2、HO-1等の発現誘導剤、酸化ストレス性疾患の予防及び/又は治療剤。【選択図】なし
