MONOMÈRE POLYPEPTIDIQUE COMPOSITE, AGRÉGAT DUDIT MONOMÈRE POLYPEPTIDIQUE COMPOSITE AYANT UNE FONCTION DE PÉNÉTRATION CELLULAIRE, ET VACCIN DE COMPOSANT DE NOROVIRUS POUR ADMINISTRATION SOUS-CUTANÉE, INTRADERMIQUE, PERCUTANÉE OU INTRAMUSCULAIRE ET AYANT LEDIT AGRÉGAT EN TANT QUE COMPOSANT EFFICACE DE CELUI-CI
Denka Company Limited;The Kitasato Institute;Tokyo Institute of Technology;JAPAN AS REPRESENTED BY THE DIRECTOR-GENERAL OF NATIONAL INSTITUTE OF INFECTIOUS DISEASES
The present invention addresses the issue of providing: a norovirus component vaccine for subcutaneous, intradermal, percutaneous, or intramuscular administration, that is capable of easily immunizing target cells； a molecular needle aggregate being an effective component thereof； and a production method therefor. A norovirus component vaccine is provided that has as an effective component thereof an aggregate including a hexamer having two molecules of a trimer of a molecular needle indicated by formula (1) bound thereto. W-L-X-Y (1) [In the formula, W indicates a P domain amino acid sequence in a norovirus capsid protein that is the immunogen, Lindicates a first linker sequence having 0-100 amino acids, X indicates an amino acid sequence of SEQ ID No. 1, Y indicates an amino acid sequence in a cell introduction area, and n indicates an integer of 1-3.]
