The present disclosure describes for at least two zones of selective thermal therapy of the body. Three-port extracorporeal circuits are described that can be used to establish at least two zones of selective thermal therapy of the body. The example three-port extracorporeal circuit includes a branching section that provides for setting the temperature of blood injected into two different portions of the body at differing temperature levels, to provide at least two zones of selective thermal therapy.本發明描述身體之至少兩個選擇性熱治療之區域。描述可用來建立身體之至少兩個選擇性熱治療之區域之三埠體外環路。該例示性三埠體外環路包含一分支區段,該分支區段將注入至身體之兩個不同部分中之血液之溫度設定於不同溫度位準,以提供至少兩個選擇性熱治療之區域。200‧‧‧體外環路206‧‧‧泵系統208‧‧‧熱交換器210‧‧‧注入器構件212‧‧‧脈管注入點214‧‧‧血液