CHEN, LI,FENG, LICHUN,FENG, SONG,GAO, LU,GUO, TAO,HUANG, MENGWEI,LIANG, CHUNGEN,LIU, YONGFU,WANG, LISHA,WONG, JASON CHRISTOPHER,WU, JIM ZHEN,WU, XIHAN,YUN, HONGYING,ZHENG, XIUFANG
申请号：
PE0001872014
公开号：
PE21482014A1
申请日:
2012.08.08
申请国别(地区):
PE
年份:
2015
代理人:
摘要：
Refers to a compound of formula (i) where R1, R2 and R3 are h, halogen or alkyl independently alkyl R4 is H, or C1 - C6 R5 or R6 H is H, halogen, halogen, Hydroxy, among others R7 is H, halogen, alkyl of C1 - C6 among others R8 is H or c1-c6 alkoxy, halogen R9 is H, alkyl C1 - C 6 u = U = H is R10 or or is N - or C - R11, where the R11 is H, alkyl, halogen,Among others, X is - CH2 -, - O -, - NH -, among others and it is CH or N q h, halogen, alkyl of C1 - C6 among others. Preferred compounds are: N - [(3 - aminooxetan - 3 - yl) methyl 2 - (4 - methoxy - dioxide 1.1 - 2.3 - di Hydro - 1.4 - benzotiazepin - 2 (5H) - yl) - 6 - - 4 Methylquinoline Amine, N - [3 - (3 - aminooxetan - yl) methyl) - 2 - (5 - fluoro - dioxide 1.1 - 2.3 - di Hydro - 1.4 - benzotiazepin - 2 (5H) - yl) - 6 - - 4 Methylquinoline Amine, among others.It also relates to a Pharmaceutical composition, which is useful for the Treatment or prophylaxis of respiratory syncytial virus infection.REFERIDO A UN COMPUESTO DE LA FORMULA (I), DONDE R1, R2 Y R3 SON H, HALOGENO O ALQUILO DE FORMA INDEPENDIENTE R4 ES H, O ALQUILO C1-C6 R5 ES H O HALOGENO R6 ES H, HALOGENO, HIDROXI, ENTRE OTROS R7 ES H, HALOGENO, ALQUILO C1-C6, ENTRE OTROSR8 ES H, HALOGENO O ALCOXI C1-C6 R9 ES H, ALQUILO C1-C6 U =O R10 ES H U =O A ES N O -C-R11, DONDE DICHO R11 ES H, HALOGENO, ALQUILO, ENTRE OTROS X ES -CH2-, -O-, -NH-, ENTRE OTROSY ES -CH- O N Q ES H, HALOGENO, ALQUILO C1-C6 ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-[(3-AMINOOXETAN-3-IL)METIL-2-(8-METOXI-1,1-DIOXIDO-2,3-DI-HIDRO-1,4-BENZOTIAZEPIN-4(5H)-IL)-6-METILQUINOLINA-4-AMINA, N-[(3-AMINOOXETAN-3-IL)METIL)-2-(8-FLUOR-1,1-DIOXIDO-2,3-DI-HIDRO-1,4-BENZOTIAZEPIN-4(5H)-IL)-6-METILQUINOLINA-4-AMINA, ENTER OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA, QUE ES UTIL PARA EL TRATAMIENTO O PROFILAXIS DE LA INFECCION DEL VIRUS SINCICIAL RESPIRATORIO.
