Université Montpellier II;INSERM (Institut National de la Santé et de la Recherche Médicale);Centre National de la Recherche Scientifique - CNRS;Universite de Montpellier 1
发明人:
申请号：
EP18183987.9
公开号：
EP3415616A1
申请日:
2012.04.10
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
The invention relates to a method for reprogramming cells from aged donors or senescent cells to pluripotent cells that have lost marks of senescence. In particular, the invention relates to an ex vivo method for preparing induced pluripotent stem cells (iPSCs) from a target cell population comprising cells from aged donors or senescent cells, said method comprising the steps of culturing said target cell population under appropriate conditions for reprogramming said cells into iPSCs, wherein said appropriate conditions comprises increasing expression in said target cells, of at least the following reprogramming factors: Oct4, Klf4, Sox2, c-Myc, Lin28 and, optionally Nanog.
