FORMULATIONS DE TAMPON POUR AMELIORER LA STABILITE D'ANTICORPS

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专利权人:

INC.;ONCOBIOLOGICS

发明人:

GUTKA, HITEN,TADDEI, MARIA,CHEUNG, JESSICA

申请号：

CA3013336

公开号：

CA3013336A1

申请日:

2017.02.01

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

The disclosure provides buffered formulations of adalimumab. The formulations comprise a buffer comprising an acetate salt, sorbitol, histidine and/or a histidine salt and optionally arginine and/or an arginine salt, and polysorbate 80. The formulations have an acidic pH, and enhance the thermal, conformational and colloidal stability of antibodies, including the adalimumab antibody.

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