Versitech Limited;Centre National de la Recherche Scientifique;Université d'Aix-Marseille;The Chinese University of Hong Kong
发明人:
Alice S. T. Wong,Jing Ma,Ling Peng,K. W. Lo
申请号：
US15459806
公开号：
US10421968B2
申请日:
2017.03.15
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The invention pertains to amphiphilic dendrimers complexed with Bcl3 siRNA. The amphiphilic dendriplexes described herein are biodegradable and exhibit enhanced siRNA delivery. The amphiphilic dendriplexes containing Bcl3 siRNA inhibit cancer cell/tumor growth in vitro and in vivo without toxicity. Accordingly, an embodiment of the invention provides a method of treating a cancer, particularly, nasopharyngeal carcinoma, by administering to a subject in need thereof, a therapeutic amount of amphiphilic dendrimers complexed with Bcl3 siRNA. Pharmaceutical compositions containing the amphiphilic dendrimers complexed with Bcl3 siRNA are also provided.
