Hoarty, Michelle Denise,Dhamnaskar, Ketki Ashok,Elbaum, Daniel,Josephson, Kristopher,Larson, Kelley Cronin,Ma, Zhong,Nims, Nathan Ezekiel,Ricardo, Alonso,Seyb, Kathleen,Tang, Guo-Qing,Treco, Douglas A
申请号：
NZ72742015
公开号：
NZ727420A
申请日:
2015.06.12
申请国别(地区):
NZ
年份:
2018
代理人:
摘要：
The invention provides polypeptides of the formula R1-Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa6-Xaa7-Xaa8-Xaa9-Xaa10-Xaa11-Xaa12-Xaa13-Xaa14-Xaa15, wherein: a. R1 is an acetyl group； b. Xaa1 is Lys； c. Xaa2 is Val； d. Xaa3 is Glu； e. Xaa4 is Arg； f. Xaa5 is Phe； g. Xaa6 is Asp； h. Xaa7 is N-methyl-aspartic acid； i. Xaa8 is tert-butylglycine； j. Xaa9 is Tyr； k. Xaa10 is 7-azatryptophan； l. Xaa11 is Glu； m. Xaa12 is Tyr； n. Xaa13 is Pro； o. Xaa14 is cyclohexylglycine； and p. Xaa15 is selected from the group consisting of N-epsilon-(PEG24-gamma-glutamic acid-N-αlpha-hexadecanoyl)lysine (B28), norvaline, Lys, and N-epsilon-palmitoyl lysine. Also provided are methods of utilizing such polypeptides as therapeutics.
