The present invention concerns an innovative biological prosthesis (1) designed for Reconstructive Surgery of the Pelvic Floor allowing central and rear defect repair. The innovative prosthesis in made of biological material (for example bovine pericardium) and comprises a proximal edge (6), a distal edge (7), a preferential direction A from the proximal to the distal edge, and four flaps, two of them (5a, 5b) distributed symmetrically with respect to the direction A at the proximal edge (6) and two (3, 4) asymmetrically distally to the median line of the prosthesis. This combination of material and shape allows a three-dimensional positioning of the prosthesis during surgery, replacing the damaged tissues effectively and mitigating the side effects.