The present invention relates to C-20 steroid compounds, compositions and methods of use thereof to treat, minimize and/or prevent traumatic brain injury (TBI), including severe TBI, moderate TBI and mild TBI, including concussions.本發明係關於C-20類固醇化合物、其組成物及用於治療、最小化及/或預防創傷性腦損傷(TBI)之使用方法,所述創傷性腦損傷包含重度TBI、中度TBI及輕度TBI,包含震盪。