PROBLEM TO BE SOLVED: To provide pharmaceutical products having a long-lasting analgesic effect, a cartilage protective effect, and an anti-inflammatory effect for a long term by a single injection.SOLUTION: A solution comprises a cross-linked hyaluronic acid derivative wherein part of functional groups of a hyaluronic acid are cross-linked with a cross-linking group to the cross-linking extent of 1 to 7.5% based on a total number of constituent disaccharide unit of hyaluronic acid, wherein the cross-linking group is a residue of cinnamic acid or cinnamic acid derivatives, a degree of substitution of the cross-linking group is from 10% to 25%, and a degree of cross-linking in the cross-linked hyaluronic acid derivative is from 10% to 30%.COPYRIGHT: (C)2014,JPO&INPIT【課題】1回の注射により、持続的鎮痛効果、長い間の軟骨の保護効果および抗炎症効果を有する医薬の提供。【解決手段】ヒアルロン酸の官能基の一部が、ヒアルロン酸の構成二糖単位の総数に対し、架橋点が1%~7.5%の割合で架橋基により架橋された架橋ヒアルロン酸誘導体を含有する溶液であって、架橋基がケイ皮酸またはケイ皮酸誘導体の残基であり、架橋基の導入率が10%~25%であり、そして架橋ヒアルロン酸誘導体の架橋率が10%~30%であることを特徴とする溶液。【選択図】なし
