The invention provides compounds as hepatitis C virus inhibitors and pharmaceutical uses thereof. Specifically, the invention provides compounds of Formula (I) or a stereoisomer, a tautomer, an enantiomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, which can be used for treating HCV infection or hepatitis C disorders. Furthermore, the invention provides pharmaceutical compositions containing the compound disclosed herein and the methods of using of the compound or pharmaceutical compositions thereof in the treatment of HCV infection or HCV disorders.本發明涉及作為丙型肝炎抑制劑的化合物及其在藥物中的應用,具體地提供如式(I)所示的化合物或其立體異構體、互變異構體、對映異構體、氮氧化物、水合物、溶劑化物、代謝產物、藥學上可接受的鹽或前藥,用於治療丙型肝炎病毒(HCV)感染或丙型肝炎疾病。本發明還揭露了含有這樣的化合物的藥物組合物和使用本發明化合物或其藥物組合物用於製備治療HCV感染或丙型肝炎疾病之藥物的用途。