Dry anti-microbial powder is applied to an incision or wound and surrounding area. A skin closure device is applied to the incision or wound. The incision or wound is closed, either before the closure device is applied or with closure device application. A sterile island dressing is then be applied over the incision or wound with the closure device and anti-microbial powder applied. The absorbent pad of the dressing can be applied directly over the incision or wound to absorb excess blood, pus, or other exudate. The anti-microbial powder mixes with the exudate before or as the exudate is absorbed. The anti-microbial powder in the exudate mixture reduces bacterial and/or microbial growth in the mixture, thereby reducing the infection risk to the closed incision or wound, as well as reducing fouling of the wound dressing and undesirable smells.