The invention relates to negative T-cell signal inducing chimeric antigen receptor (N-CAR or i-CAR) and to T-cells comprising such N-CAR as well as a positive T-cell signal inducing CAR (P-CAR) as well as their use in therapy.Linvention concerne un récepteur dantigène chimérique induisant un signal lymphocytaire T négatif (N-CAR ou i-CAR) et des lymphocytes T comprenant ce N-CAR, ainsi quun CAR induisant un signal lymphocytaire T positif (P-CAR), et leur utilisation à des fins thérapeutiques.