The present invention concerns the use of compounds for preventing and/or treating osteoporosis, for stimulating bone formation, for stimulating bone remodeling, for stimulating the differentiation and mineralization of osteoblasts, for inhibiting bone resorption and for modulating serum level of adiponectin in a subject. These uses have been found for compounds represented by Formula I and pharmaceutically acceptable salts thereof,wherein A is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(O)—；(CH2)n—；CH3 or CH(OH)—；(CH2)n—；CH3 wherein n is 3 or 4； R1 is H, F or OH； R2 is H, F, OH, C6 alkyl, C5 alkenyl, C6 alkenyl, C(O)(CH2)n—；CH3 or CH(OH)—；(CH2)n—；CH3 wherein n is 3 or 4； R3 is H, F, OH or CH2Ph； R4 is H, F, or OH； Q is 1) (CH2)mC(O)OH wherein m is 1 or 2, 2) CH(F)—；C(O)OH, 3) CF2—；C(O)OH, or 4) C(O)—；C(O)OH.
