Disclosed are crystalline polymorphic forms of the malic acid salt of (Z)-N-[2- (diethylamino)ethyl]-5-[(5-fluoro-l,2-dihydro-2-oxo-3H-indol-3-yliden)methyl]-2,4- dimethyl-1H-pyrrole-3-carboxamide, sunitinib malate, including crystalline Forms III, IV, V, VI and VII. Also disclosed are processes for preparing crystalline polymorphic forms of sunitinib malate and pharmaceutical compositions comprising sunitinib malate.L’invention concerne des formes polymorphes cristallines du sel de l’acide malique du (Z)-N-[2-(diéthylamino)éthyl]-5-[(5-fluoro-l,2-dihydro-2-oxo-3H-indol-3-ylidène)méthyl]-2,4-diméthyl-1H-pyrrole-3-carboxamide, malate de sunitinib, y compris les formes cristallines III, IV, V, VI et VII. L’invention concerne également des procédés de préparation de formes polymorphes cristallines du malate de sunitinib et de compositions pharmaceutiques qui comprennent du malate de sunitinib.
