A diaper with removable wipe pouch. The diaper includes a flexible base having a front panel and a rear panel. The flexible base is movable between an open configuration and a closed configuration, wherein the front panel is secured to the rear panel when in the closed configuration, such that an upper opening is defined. The flexible base further includes arcuate lateral edges defining a pair of leg openings when the flexible base is in the closed configuration. A pouch is removably secured to the rear panel, wherein at least one cleaning wipe is disposed within an interior volume thereof. The pouch is secured to the rear panel via a continuous perforated seam disposed about a perimeter of the pouch.
