Tenhoor, Christopher,Muruganandam, Arumugam,Ladner, Robert Charles,Wood, Clive,Bitonti, Alan J.,Stattel, James,McDonnell, Kevin,Liu, Liming,Dumont, Jennifer,Sato, Aaron
申请号：
AU2015200004
公开号：
AU2015200004A1
申请日:
2015.01.02
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
#$%^&*AU2015200004A120150129.pdf#####ABSTRACT This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoinmune disorders. See Fig. 36.WO 2009/131702 PCT/US2009/002536 36/46 FIGURE 30 - (a, z) ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS - (a, z) GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKK - (f) ----------------------------------------------- - (a, z) VEIPKS...T HTPPCAPELLGGPSVFLFPPKPKDTLMISRT PEVTCVVV - (a, z) D - (a, z) LN G KEYKCKVSNiKALPAVI FKITI SKAKGQPREPQVYTLPPSPREPQVYT - (a,z) LPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLD - (f)------E-M---------------------------------------- (a,z) SDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK* ------------------------------------~---~~~~ (a, z) (SEQ ID NO: 115) (f) (SEQ ID NO: 116) SUBSTITUTE SHEET (RULE 26)
