Methods, apparatus and systems for modifying hair follicles are disclosed herein. A method for modifying hair follicles may comprise inserting a tissue dissecting and modifying wand (TDM) into an incision in a patients skin. The TDM may comprise a tip having a plurality of protrusions with lysing segments positioned between the protrusions. The TDM may also comprise an energy window positioned on top of the TDM that is configured to deliver energy to incapacitate hair follicles. After separating tissue using the lysing segment(s) to define a target region, the energy window may be activated and moved around within the target region to incapacitate hair follicles. In some implementations, the energy window may be activated prior to separating the tissue such that the tissue is separated while hair follicles are incapacitated within the target region.
