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TABLET CONTAINING 1-CYCLOPROPYL-8-(DIFLUOROMETHOXY)-7-[(1R)-1-METHYL-2, 3-DIHYDRO-1H-ISOINDOLE-5-YL]-4-OXO-1, 4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID METHANESULFONIC ACID HYDRATE
专利权人:
TOYAMA CHEMICAL CO.; LTD.
发明人:
KAKUDA, SAHOE,MIYAZAKI, TSUTOMU,OKADA, KOTARO
申请号:
SG11201402597W
公开号:
SG11201402597WA
申请日:
2012.11.29
申请国别(地区):
SG
年份:
2014
代理人:
摘要:
(1) A tablet according to the present invention has a percentage content of 1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-1-methyl-2, 3-dihydro-1H-isoindole-5-yl]-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid methanesulfonic acid hydrate of between 80 wt% and 97.5 wt%. (2) The tablet is smaller in size than 200mg of a commercially available Geninax tablet. (3) As a result, drug compliance is improved, (4) leachability is high, and (5) hardness and friability are high. (6) As a result, the present invention withstands film coating and transportation, and is useful as a tablet of methanesulfonic acid hydrate of chemical compound A.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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