COMPOSITION POUR LA PREVENTION OU LE TRAITEMENT DE LA CARDIOPATHIE ISCHEMIQUE COMPRENANT UN INHIBITEUR CONTRE LA SYNTHESE D'ALBUMINE AGE OU LA LIBERATION DE CELLULES DU SYSTEME PHAGOCYTAIRE MONONUCLEAIRE COMME INGREDIENT ACTIF
GACHON UNIVERSITY OF INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人:
LEE, BONG HEE,BYUN, KYUNG HEE
申请号：
CA2964760
公开号：
CA2964760C
申请日:
2012.11.12
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
Disclosed is a pharmaceutical composition for the prevention or treatment of ischemic heart diseases, comprising as an active ingredient an inhibitor which acts to restrain mononuclear phagocyte system cells from synthesizing or releasing AGE-albumin, which induces the apoptosis of cardiomyocytes upon the onset of the ischemic heart disease. Also, a method is provided for screening an inhibitor against the AGE-albumin synthesis or release of mononuclear phagocyte system cells. Inhibitory or suppressive of AGE-albumin- induced cell death, the pharmaceutical composition comprising as an active ingredient an inhibitor against the AGE-albumin synthesis or release of mononuclear phagocyte system cells can be applied to the prevention or treatment of a wide spectrum of ischemic heart diseases including myocardial infarction.
