Various embodiments of methods and systems are provided for image reconstruction in photoacoustic tomography. In one embodiment, among others, a method includes obtaining photoacoustic time-domain data reconstructing an image from the photoacoustic time-domain data using total-variation minimization based photoacoustic tomography reconstruction and providing the reconstructed image for rendering on a display device. In another embodiment, a system includes a computing device and an image reconstruction program executable in the computing device. The image reconstruction program includes logic that obtains photoacoustic time-domain data logic that reconstructs an image from the photoacoustic time-domain data using total-variation minimization based photoacoustic tomography reconstruction and logic that provides the reconstructed image for rendering on a display device.
