Systems and methods disclosed herein provide efficacious therapies based on delivery of combinations of thermoceuticals, electroceuticals, ultrasound via computer-implemented systems. Sensors coupled to the device are configured to measure changes in tissue and bone conditions, physiological data resulting from the delivered therapy. The personalized therapy can be adjusted based on the changes in the physiological or sensor data and/or patient feedback. The patient information, information about the applied therapy, and therapy outcome information can be added to the analytics database.
