BECK, Hilary Plake,BOOKER, Shon Keith,BREGMAN, Howard,CEE, Victor J.,CHAKKA, Nagasree,CUSHING, Timothy D.,EPSTEIN, Oleg,FOX, Brian M.,GEUNS-MEYER, Stephanie,HAO, Xiaolin,HIBIYA, Kenta,HIRATA, Jun,HUA,
申请号：
ES15713244
公开号：
ES2673279T3
申请日:
2015.02.27
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof: ** Formula ** wherein: R1 is selected from F, Cl, Br, a C1 to C6 alkyl group substituted with 0, 1, 2 or 3 Ra groups and a C3 to C8 cycloalkyl group substituted with 0, 1, 2 or 3 Ra groups； Y is selected from a C4 to C6 cycloalkyl group, a C6 to C9 bicycloalkyl group and a C6 to C9 spiroalkyl group, all of which are substituted with an R2, 0 or 1 R6 group and 0.1, 2 or 3 R7 groups ； R2 is selected from -OH, -CO2H, -SO3H, -CONH2, -SO2NH2, a group (C1 to C6 alkoxy) substituted carbonyl 0, 1, 2 or 3 Rc groups, a group (C1 to C6 alkyl) substituted aminocarbonyl 0 , 1, 2 or 3 Rc groups, a C1 to C6 alkylsulfonyl group substituted with 0, 1, 2 or 3 Rc groups, a C1 to C6 alkylaminosulfonyl group substituted with 0, 1, 2 or 3 Rc groups, a group (hydroxycarbonyl) (C1 to C3 alkyl) substituted with 0, 1, 2 or 3 Rc groups, a group (C1 to C6 alkoxy) carbonyl (C1 to C3 alkyl) substituted with 0, 1, 2 or 3 Rc groups, a group (C1 alkyl to C6) sulfonyl (C1 to C3 alkyl) substituted with 0, 1, 2 or 3 Rc groups and a group (C2 to C6 alkenyl) (C1 to C3 alkyl) substituted with 0, 1, 2 or 3 Rc groups； R6 and R7 are independently selected from H, F, -OH, -NH2, -CN, a C1 to C6 alkyl group substituted with 0, 1, 2 or 3 Rb groups and a C1 to C6 alkoxy group substituted with 0, 1, 2 or 3 Rb groups； R3 is selected from H, F, Cl, -CH3 and -CF3； R4 is selected from a C1 to C6 alkyl group substituted with 0, 1, 2, 3, 4 or 5 Re groups, a group (C2 to C6 alkenyl) (C1 to C3 alkyl) substituted with 0, 1, 2, 3, 4 or 5 Re groups, a group (C2 to C6 alkynyl) (C1 to C3 alkyl) group substituted with 0, 1, 2, 3, 4 or 5 Re groups, a group (C1 to C6 alkoxy) (C2 to C4 alkyl ) substituted with 0, 1, 2, 3, 4 or 5 Re groups, a group (C6 to C10 aryl) (C1 to C3 alkyl) substituted with 0, 1, 2, 3, 4 or 5 Rf groups, a group ( 5 or 10-membered heteroaryl) (C1 to C3 alkyl) substituted with 0, 1, 2, 3, 4 or 5 Rf groups, a C3 to C8 cyc
