GOSUDARSTVENNOE BJUDZHETNOE OBRAZOVATELNOE UCHREZHDENIE VYSSHEGO PROFESSIONALNOGO OBRAZOVANIJA "SEVERO-ZAPADNYJ GOSUDARSTVENNYJ MEDITSINSKIJ UNIVERSITET IM. I.I. MECHNIKOVA" MINISTERSTVA ZDRAVOOKHRANE
发明人:
PANTELEEV ALEKSANDR MIKHAJLOVICH,Пантелеев Александр Михайлович
申请号：
RU2011154709/15
公开号：
RU0002482848C1
申请日:
2011.12.30
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
FIELD: medicine.SUBSTANCE: invention refers to medicine, particularly to phthisiology and infectious diseases, and may be used for treating the patients with drug-resistant tuberculosis and HIV infection. For this purpose, with underlying high-active antiretroviral therapy (HA ART), the patients state is clinically assessed, and observing the deterioration, temperature rise, developing inflammatory process in the involved organs, prednisolone 0.5 mg/kg is administered once daily orally for 10-12 days. After termination of the therapeutic course, the clinical parameters are assessed observing the normalisation thereof enables stating the presence of the inflammatory immune reconstitution syndrome in the patients with drug-resistant tuberculosis and HIV infection with underlying the HAART. The prednisolone therapy is continued up to 3 weeks. In the absence of a positive effect of the use of prednisolone, the developing disease is associated by the progression of drug-resistance of tuberculosis mycobacteria, and the prednisolone therapy is withdrawn herewith correcting the anti-tuberculosis therapeutic regimen by prescribing the second-line anti-tuberculosis preparations.EFFECT: method ensured providing higher clinical effectiveness in the patients with drug-resistant tuberculosis and HIV infection by eliminating the inadequate intensive therapy receiving the second-line anti-tuberculosis preparations causing a risk of developing side effects.2 exИзобретение относится к медицине, а именно фтизиатрии и инфекционным болезням, и может быть использовано для лечения больных с лекарственно-устойчивым туберкулезом и ВИЧ-инфекцией. Для этого на фоне применения высокоактивной антиретровирусной терапии (ВААРТ) проводят клиническую оценку состояния больного, и при ухудшении общего состояния, повышении температуры тела, прогрессировании воспалительного процесса в пораженных органах больному вводят преднизолон в дозе 0,5 мг/кг однократно в сутки перорально в течение 10-12 дней. Пос
