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Support de médicament et kit de support de médicament permettant d'inhiber la fibrose
专利权人:
NITTO DENKO CORPORATION
发明人:
申请号:
EP13193438.2
公开号:
EP2730277A3
申请日:
2005.12.22
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
A stellate cell-specific drug carrier containing a retinoid derivative and/or a vitamin A analog as a constituent; a drug delivery method with the use of the same; a drug containing the same; and a therapeutic method with the use of the drug. By binding a drug carrier to a retinoid derivative such as vitamin A or a vitamin A analog or encapsulating the same in the drug carrier, a drug for therapeutic use can be delivered specifically to astrocytes. As a result, a stellate cell-related disease can be efficiently and effectively inhibited or prevented while minimizing side effects. As the drug inhibiting the activity or growth of stellate cells, for example, a siRNA against HSP47 which is a collagen-specific molecule chaperone may be encapsulated in the drug carrier. Thus, the secretion of type I to type IV collagens can be inhibited at the same time and, in its turn, fibrosis can be effectively inhibited.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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