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METHOD FOR DIAGNOSING MYOCARDIAL ISCHEMIA BY VOLUMETRIC COMPUTED TOMOGRAPHY IN COMBINATION WITH PHARMACOLOGICAL TEST OF ADENOSINE TRIPHOSPHATE
专利权人:
Federalnoe gosudarstvennoe byudzhetnoe uchrezhdenie "Natsionalnyj Meditsinskij Issledovatelskij Tsentr Kardiologii" Ministerstva zdravookhraneniya Rossijskoj Federatsii (FGBU "NMITS kardiologii" Minzd
发明人:
Soboleva Galina Nikolaevna (RU),Соболева Галина Николаевна (RU),Gaman Svetlana Anatolevna (RU),Гаман Светлана Анатольевна (RU),Ternovoj Sergej Konstantinovich (RU),Терновой Сергей Константинович (RU)
申请号:
RU2019128543
公开号:
RU0002729030C1
申请日:
2019.09.11
申请国别(地区):
RU
年份:
2020
代理人:
摘要:
FIELD: medicine.SUBSTANCE: invention relates to the field of medicine, namely to cardiology. Myocardial perfusion is analyzed by volumetric computed tomography (VCT), with pharmacological breakdown of sodium adenosine triphosphate (ATP), which is performed in two stages. At the first stage, the examination is carried out at rest with introduction of a contrast agent. At the second stage - not less than 20 minutes after the first introduction of the contrast preparation, the study is carried out in a stress state which is induced by infusion through a peripheral venous catheter of 1 % ATP solution at rate of 0.10–0.20 mg/kg in minute for 1–5 minutes. At the same time from the beginning of infusion of ATP or when the criteria for stopping the pharmacological test, such as the occurrence of retrosternal pains and/or ischemic ECG dynamics, without interrupting the infusion, 60–90 mg of a non-ionic iodine-containing contrast preparation with concentration of 350–370 mg of iodine/ml is introduced intravenously bolus at rate of 4–5 ml/s. At the same time at the first and second stages prior to the introduction of the contrast preparation, a natural examination is carried out, all stages of the VCT are necessarily performed with prospective synchronization with the ECG in the diastole phase, where the trigger is set for 65–93 % of the cardiac cycle phase. ECG electrodes are applied so that they are outside the field of the projection of the heart with the possibility of excluding artefacts from them in the left ventricular myocardial perfusion assessment zone. At the second stage, additional blood pressure control is performed, and as a result of the VCT, tomographs are taken without artifacts from LV motion, which characterize at least one phase of the cardiac cycle, at least 360 sections. Weakening of the myocardial density (MD) is determined on the basis of which the following values are calculated: a contrast index (CI) as a relation of myocardial infarction on the enti
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中国工程科技知识中心
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http://www.ckcest.cn/home/
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