KIM, JI HAN,김지한,KIM, JE HAK,김제학,LEE, JOON KWANG,이준광,JUNG, HAHN SUN,정한선,HAN, NAM SEOK,한남석,PARK, YONG,박용,KANG, SEUNG HOON,강승훈,JEONG, HEE JIN,정희진,LEE, KYUNG TAE,이경태,CHOI, HYE EUN,최혜은,CHI, YONG HA,지용하,LEE,LEE, J
申请号：
KR1020110074638
公开号：
KR1020130013163A
申请日:
2011.07.27
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A pharmaceutical composition containing a compound which suppresses angiogenesis is provided to prevent and treat diseases caused by angiogenesis suppression abnormality. CONSTITUTION: A compound which suppresses angiogenesis is denoted by chemical formula I. The compound of chemical formula I or pharmaceutically acceptable salts thereof is 2-(1-benzylpiperidine-4-ylamino)-N-(3-chlorphenyl)nicotiamide&lsqb；103&rsqb； or pharmaceutically acceptable salts thereof. A method or preparing the compound of chemical formula I comprises a step of reacting a compound of chemical formula II and a compound of chemical formula III under the presence of a base. The base is triethyl amine, N,N-diisopropylethyl amine, N-methylmorpholine, DBU(1,8-diazabicyclo&lsqb；5.4.0&rsqb；undec-7-ene), N-methylpiperidine, 4-dimethylaminopyridine, N,N-dimethylaniline, 2,6-lutidine, 4-N,N-dimethylaminopyridine, or pyridine. A pharmaceutical composition for preventing or treating diseases or symptoms caused by VEGF(Vascular Endothelial Growth Factor) abnormality contains the compound of chemical formula I or the salts.본 발명은 혈관생성억제 활성을 가지는 [화학식 I]의 화합물 또는 이의 약제학적으로 허용 가능한 염, 이의 제조방법 및 이를 포함하는 약학적 조성물을 제공한다. 본 발명의 [화학식 I]의 화합물은 혈관생성억제 활성이 우수하여, 혈관생성억제 활성 이상에 의해 유발된 질환의 예방 및 치료에 유용하게 사용될 수 있다.
