JEAN C. CALIFANO,WENKE LI,DANIEL D. CASPI,CHARLES A. FLENTGE,MARY E. BELLIZZI,TAMMIE K. JINKERSON,DOUGLAS K. HUTCHINSON,DAVID A. DGOEY,JOHN K. PRATT,ALLAN C. KRUEGER,JOHN T. RANDOLPH,CHRISTOPHER E. MO
申请号：
ARP130103220
公开号：
AR092505A2
申请日:
2013.09.10
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
Effective compounds to inhibit replication of hepatitis C virus (HCV). This also relates to processes for preparing such Compounds, compositions comprising such compounds and Methods of using them to treat hcv infection.Claim 1: a compound of formula (1) or a pharmaceutically acceptable Salt thereof, wherein: X is a compound of formula (2), and is optionally substituted with one or more ra where X is N and is directly linked to l u00b3 - D； l u00b9, L u00b2 and l u00b3 are links； The Comp Ecause of formula (3), and is optionally substituted with one or more ra； b is a compound of formula (4),And is optionally substituted with one or more ra； d is a compound of formula (5), and each route is selected independently of Rd, and J is carbociclo c u2083 u208b u2086 or heterocycle of 3 to 6 members and is optionally substituted with one or more ra RC are each independently selected； OJ of RC, RD are each independently selected from R u00b2 and r u2075, RD；Taken together with the Atoms to which they are United, form the rest of formula (6) which is optionally substituted with one or more r u2079 ra； and r u00b9 u00b2 taken together with the Atoms to which they are United, form the rest of formula (6) which is optionally substituted with one or more Ra - Rd is each independently selected from - LY - C (o) n (RB) C (o) - RD or - C (o) - ly n (RB) C (o) o - RD,Ly is and where each independently each LS； Rd is selected independently in each case between Hydrogen or ra ra is selected independently in each case between Halogen, Nitro, fosfonoxi, phosphono OXO, tioxo, cyano, or - LS - Re, RB is selected in standalone form And in each case between Hydrogen or alkyl c u2081 u208b u2086, alquenilo c u2082 u208b u2086 or alquinilo c u2082 u208b u2086,Each of which is optionally replaced independently in each case with one or more substituents selected from Halogen, Hydroxy, mercapto, amino, carboxy, Nitro, fosfonoxi phosphono OXO, tioxo Formilo,,,,Cyano or carbociclo or heterocycle of
