Implantable drug infusion devices, systems and methods for delivering therapeutic substance to a subject that include a bulkhead and an attached reservoir formed by an elastic bladder are disclosed. When filled with therapeutic substance, the elastic bladder is elastically expanded such that the therapeutic substance is held at a pressure above ambient pressure. As the therapeutic substance is removed from the reservoir, the bladder collapses and may conform to the shape of the bulkhead surface over which it is located.
