DUNCAN, IAIN W.,KESICKI, EDWARD A.,OSBORNE, CARL G.,SCHWIETERMAN, WILLIAM D.,JACOBSON, IRINA
申请号：
CA2730377
公开号：
CA2730377C
申请日:
2009.07.10
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present disclosure is directed to compositionsand methods which utilize the tetracycline scaffold,preferably the scaffold of minocycline, and which significantlylack antibiotic activity. The compounds have neuroprotectiveattributes without interfering with the drugs capacityto pass through the blood brain barrier. These compoundshave neuroprotective activity because of their inhibitionof neuronal cell cycle progression. The compoundsare characterized m part by a fifth ring joining positions 9and 10.
