Cornfeld, Mark J.,Kumar, Rakesh,Morris, Shannon Renae
申请号：
AU2014330779
公开号：
AU2014330779A1
申请日:
2014.10.01
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
A novel combination comprising a 17 α-hydroxylase/C17,20 lyase inhibitor, for example: (3β)-17-(pyridin-3-yl)androsta-5,16-dien-3-ol or a pharmaceutically acceptable salt or ester thereof, and an AKT inhibitor, for example: N-{(1S)-2-amino-1-[(3- fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2- thiophenecarboxamide, or a pharmaceutically acceptable salt thereof, and optional additional antineoplastic agents； pharmaceutical compositions comprising the same and methods of using such combinations and compositions in the treatment of conditions in which the inhibition of 17 α-hydroxylase/C17,20 lyase and/or AKT inhibition is beneficial, e.g., cancer.
