A burr hole plug comprises a plug base configured for being mounted around a burr hole. The plug base includes an aperture through which an elongated medical device exiting the burr hole may pass. The burr hole plug further comprises a retainer configured for being mounted within the aperture of the plug base to secure the medical device. A method of performing a medical procedure on a patient may comprise introducing the elongated medical device through a burr hole of the patient and into the brain tissue of the patient, mounting the plug base around a burr hole, such that the medical device extends through an aperture of the plug base, mounting the retainer within the aperture of the plug base, and actuating the retainer to secure the medical device.
