Isolated polypeptides of CD44 are provided. Accordingly there is provided an isolated polypeptide consisting of an amino acid sequence selected from the group consisting of SEQ ID NOs: 1 3. Also provided is an isolated end capping modified polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1 3 wherein the modified polypeptide comprises an anti inflammatory activity. Also provided are compositions of matter fusion proteins and pharmaceutical compositions and their use in the treatment of inflammatory disease.